Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.

Han, Jung Min; Jeong, Seung Jae; Park, Min Chul; Kim, Gyuyoup; Kwon, Nam Hoon; Kim, Hoi Kyoung; Ha, Sang Hoon; Ryu, Sung Ho; Kim, Sunghoon

Han, Jung Min; Jeong, Seung Jae; Park, Min Chul; Kim, Gyuyoup; Kwon, Nam Hoon; Kim, Hoi Kyoung; Ha, Sang Hoon; Ryu, Sung Ho; Kim, Sunghoon.

Affiliation

Han JM; Medicinal Bioconvergence Research Center, Seoul National University, Seoul 151-742, Republic of Korea.

Cell ; 149(2): 410-24, 2012 Apr 13.

Article in En | MEDLINE | ID: mdl-22424946

Subject(s)

Leucine-tRNA Ligase/metabolism; Leucine/metabolism; Proteins/metabolism; Signal Transduction; Amino Acid Sequence; Animals; Autophagy; Cell Line; Cell Size; Humans; Leucine-tRNA Ligase/chemistry; Lysosomes/metabolism; Mechanistic Target of Rapamycin Complex 1; Molecular Sequence Data; Multiprotein Complexes; Protein Biosynthesis; Proteins/chemistry; Sequence Alignment; TOR Serine-Threonine Kinases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Proteins / Leucine / Leucine-tRNA Ligase Limits: Animals / Humans Language: En Journal: Cell Year: 2012 Document type: Article

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