Berberine inhibits the proliferation of colon cancer cells by inactivating             Wnt/ß-catenin signaling.

Wu, Ke; Yang, Qiujun; Mu, Yuqin; Zhou, Longyang; Liu, Yinzi; Zhou, Qixin; He, Baicheng

Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/ß-catenin signaling.

Wu, Ke; Yang, Qiujun; Mu, Yuqin; Zhou, Longyang; Liu, Yinzi; Zhou, Qixin; He, Baicheng.

Affiliation

Wu K; Department of Pharmacology, Chongqing Medical University, Chongqing 400016, PR China.

Int J Oncol ; 41(1): 292-8, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22469784

Subject(s)

Anticarcinogenic Agents/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Berberine/pharmacology; Cell Proliferation/drug effects; Wnt Signaling Pathway/drug effects; beta Catenin/metabolism; Adenocarcinoma/chemically induced; Adenocarcinoma/pathology; Adenocarcinoma/prevention & control; Animals; Anticarcinogenic Agents/therapeutic use; Antineoplastic Agents, Phytogenic/therapeutic use; Apoptosis/drug effects; Berberine/therapeutic use; Caspase 3/metabolism; Cell Survival/drug effects; Colonic Neoplasms/chemically induced; Colonic Neoplasms/pathology; Colonic Neoplasms/prevention & control; Dextran Sulfate; Dimethylhydrazines; Female; G1 Phase Cell Cycle Checkpoints/drug effects; Gene Expression/drug effects; Genes, Reporter; HCT116 Cells; Humans; Luciferases, Firefly/biosynthesis; Luciferases, Firefly/genetics; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; beta Catenin/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Berberine / Anticarcinogenic Agents / Cell Proliferation / Beta Catenin / Wnt Signaling Pathway / Antineoplastic Agents, Phytogenic Limits: Animals / Female / Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2012 Document type: Article Country of publication: Greece

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