The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth.

Bellou, Sofia; Karali, Evdoxia; Bagli, Eleni; Al-Maharik, Nawaf; Morbidelli, Lucia; Ziche, Marina; Adlercreutz, Herman; Murphy, Carol; Fotsis, Theodore

Bellou, Sofia; Karali, Evdoxia; Bagli, Eleni; Al-Maharik, Nawaf; Morbidelli, Lucia; Ziche, Marina; Adlercreutz, Herman; Murphy, Carol; Fotsis, Theodore.

Affiliation

Bellou S; Department of Biomedical Research, Foundation of Research and Technology-Hellas, Institute of Molecular Biology & Biotechnology, University Campus, 45110, Ioannina, Greece.

Mol Cancer ; 11: 35, 2012 May 14.

Article in En | MEDLINE | ID: mdl-22583931

Subject(s)

Angiogenesis Inhibitors/pharmacology; Isoflavones/pharmacology; Neoplasms/blood supply; Neoplasms/pathology; Neovascularization, Pathologic; Tumor Burden/drug effects; Angiogenesis Inhibitors/administration & dosage; Angiogenesis Inhibitors/chemical synthesis; Animals; Cattle; Cell Line, Tumor; Cell Movement/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; Drug Screening Assays, Antitumor; Equol/analogs & derivatives; Female; Human Umbilical Vein Endothelial Cells/drug effects; Humans; Isoflavones/administration & dosage; Isoflavones/chemical synthesis; MAP Kinase Signaling System/drug effects; Mice; Mice, Nude; Mitosis/drug effects; Neoplasms/drug therapy; Neovascularization, Pathologic/drug therapy; Vascular Endothelial Growth Factor A/pharmacology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Angiogenesis Inhibitors / Tumor Burden / Isoflavones / Neoplasms / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2012 Document type: Article Affiliation country: Greece

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