High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia.

Song, J H; Kweon, S H; Kim, H-J; Lee, T-H; Min, W-S; Kim, H-J; Kim, Y-K; Hwang, S Y; Kim, T S

Song, J H; Kweon, S H; Kim, H-J; Lee, T-H; Min, W-S; Kim, H-J; Kim, Y-K; Hwang, S Y; Kim, T S.

Affiliation

Song JH; Division of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.

Br J Cancer ; 107(1): 108-15, 2012 Jun 26.

Article in En | MEDLINE | ID: mdl-22627319

Subject(s)

Antigens, Neoplasm/genetics; DNA Topoisomerases, Type II/genetics; DNA-Binding Proteins/genetics; Leukemia, Myeloid, Acute/drug therapy; Anthracyclines/administration & dosage; Antigens, Neoplasm/metabolism; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Biomarkers, Tumor/analysis; Bone Marrow/metabolism; Cell Line, Tumor; Cytarabine/administration & dosage; DNA Topoisomerases, Type II/metabolism; DNA-Binding Proteins/metabolism; Disease-Free Survival; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute/diagnosis; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/mortality; Male; Middle Aged; Poly-ADP-Ribose Binding Proteins; Prognosis; Ribonucleoside Diphosphate Reductase/metabolism; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / DNA Topoisomerases, Type II / DNA-Binding Proteins / Antigens, Neoplasm Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans / Male / Middle aged Language: En Journal: Br J Cancer Year: 2012 Document type: Article Country of publication: United kingdom

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