17ß-Estradiol inhibits apoptotic cell death of oligodendrocytes by inhibiting RhoA-JNK3 activation after spinal cord injury.

Lee, Jee Y; Choi, Soo Y; Oh, Tae H; Yune, Tae Y

Lee, Jee Y; Choi, Soo Y; Oh, Tae H; Yune, Tae Y.

Affiliation

Lee JY; Age-Related and Brain Diseases Research Center, School of Medicine, Kyung Hee University, Medical Building 10th Floor, Dongdaemun-gu, Hoegi-dong 1, Seoul 130-701, Korea.

Endocrinology ; 153(8): 3815-27, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22700771

Subject(s)

Estradiol/pharmacology; Estradiol/therapeutic use; Mitogen-Activated Protein Kinase 10/metabolism; Oligodendroglia/cytology; Oligodendroglia/metabolism; Spinal Cord Injuries/drug therapy; Spinal Cord Injuries/metabolism; rhoA GTP-Binding Protein/metabolism; Animals; Apoptosis/drug effects; Behavior, Animal; Blotting, Western; Caspase 3/metabolism; Caspase 9/metabolism; Cells, Cultured; Enzyme Activation/drug effects; Estrogen Receptor alpha/genetics; Estrogen Receptor alpha/metabolism; Estrogen Receptor beta/genetics; Estrogen Receptor beta/metabolism; In Situ Nick-End Labeling; Male; Mitogen-Activated Protein Kinase 10/genetics; Oligodendroglia/drug effects; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Oligodendroglia / RhoA GTP-Binding Protein / Mitogen-Activated Protein Kinase 10 / Estradiol Limits: Animals Language: En Journal: Endocrinology Year: 2012 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google