Amides/therapeutic use; Diabetes Mellitus, Experimental/drug therapy; Diabetic Angiopathies/drug therapy; Diabetic Nephropathies/drug therapy; Fumarates/therapeutic use; Insulin Resistance; Amides/administration & dosage; Amides/pharmacology; Animals; Biomarkers/metabolism; Blood Glucose/metabolism; Body Weight/drug effects; DNA Fragmentation/drug effects; Diabetes Mellitus, Experimental/blood; Diabetes Mellitus, Experimental/pathology; Diabetes Mellitus, Experimental/physiopathology; Diabetic Angiopathies/blood; Diabetic Angiopathies/pathology; Diabetic Angiopathies/physiopathology; Diabetic Nephropathies/blood; Diabetic Nephropathies/pathology; Diabetic Nephropathies/physiopathology; Extracellular Matrix/drug effects; Extracellular Matrix/metabolism; Fumarates/administration & dosage; Fumarates/pharmacology; Glomerular Filtration Rate/drug effects; Glucose Transporter Type 2/metabolism; Glucose Transporter Type 4/metabolism; Hemodynamics/drug effects; Humans; Inflammation/pathology; Insulin/blood; Liver/drug effects; Liver/metabolism; Mice; Muscles/drug effects; Muscles/metabolism; ROC Curve; Rats; Rats, Wistar