NADPH oxidase 2-derived reactive oxygen species are involved in dysfunction and apoptosis of pancreatic ß-cells induced by low density lipoprotein.

Li, Miao; Dou, Lin; Jiao, Juan; Lu, Yonggang; Guo, Han-Bang; Man, Yong; Wang, Shu; Li, Jian

Li, Miao; Dou, Lin; Jiao, Juan; Lu, Yonggang; Guo, Han-Bang; Man, Yong; Wang, Shu; Li, Jian.

Affiliation

Li M; The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, No. 1 Dahua Road, Dong Dan, Beijing, China.

Cell Physiol Biochem ; 30(2): 439-49, 2012.

Article in En | MEDLINE | ID: mdl-22814241

Subject(s)

Insulin-Secreting Cells/metabolism; Membrane Glycoproteins/metabolism; NADPH Oxidases/metabolism; Reactive Oxygen Species/metabolism; Animals; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Apolipoproteins E/metabolism; Apoptosis/drug effects; Cell Line; Cholesterol/blood; Cholesterol/metabolism; Diet, High-Fat; Insulin/metabolism; Insulin-Secreting Cells/cytology; JNK Mitogen-Activated Protein Kinases/metabolism; Lipoproteins, LDL/blood; Lipoproteins, LDL/pharmacology; Male; Membrane Glycoproteins/antagonists & inhibitors; Membrane Glycoproteins/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases/antagonists & inhibitors; NADPH Oxidases/genetics; NF-kappa B/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; RNA Interference; RNA, Small Interfering/metabolism; Signal Transduction/drug effects; Tumor Suppressor Protein p53/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Reactive Oxygen Species / NADPH Oxidases / Insulin-Secreting Cells Limits: Animals Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: China Country of publication: Germany

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