The role of PPAR&#945; in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.

Barreto-Torres, Giselle; Parodi-Rullán, Rebecca; Javadov, Sabzali

The role of PPARα in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.

Barreto-Torres, Giselle; Parodi-Rullán, Rebecca; Javadov, Sabzali.

Affiliation

Barreto-Torres G; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936, USA.
Parodi-Rullán R; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936, USA.
Javadov S; Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936, USA.

Int J Mol Sci ; 13(6): 7694-7709, 2012.

Article in En | MEDLINE | ID: mdl-22837722

Subject(s)

Hypoglycemic Agents/pharmacology; Metformin/pharmacology; Mitochondria, Heart/metabolism; Myocardial Reperfusion Injury/metabolism; Myocytes, Cardiac/metabolism; PPAR alpha/metabolism; Animals; Electron Transport Complex I/metabolism; Electron Transport Complex II/metabolism; L-Lactate Dehydrogenase/metabolism; Male; Mitochondria, Heart/pathology; Myocardial Reperfusion Injury/pathology; Oxazoles/pharmacology; PPAR alpha/antagonists & inhibitors; Rats; Rats, Sprague-Dawley; Tyrosine/analogs & derivatives; Tyrosine/pharmacology

Key words

AMPK, PPARα; heart; ischemia/reperfusion; metformin; mitochondria

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocardial Reperfusion Injury / Myocytes, Cardiac / PPAR alpha / Hypoglycemic Agents / Metformin / Mitochondria, Heart Limits: Animals Language: En Journal: Int J Mol Sci Year: 2012 Document type: Article Affiliation country: United States Country of publication: Switzerland

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