Pharmacological evaluation of SN79, a sigma (&#963;) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.

Kaushal, Nidhi; Seminerio, Michael J; Robson, Matthew J; McCurdy, Christopher R; Matsumoto, Rae R

Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.

Kaushal, Nidhi; Seminerio, Michael J; Robson, Matthew J; McCurdy, Christopher R; Matsumoto, Rae R.

Affiliation

Kaushal N; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, PO Box 9500, Morgantown, WV 26506, USA.

Eur Neuropsychopharmacol ; 23(8): 960-71, 2013 Aug.

Article in En | MEDLINE | ID: mdl-22921523

Subject(s)

Benzoxazoles/therapeutic use; Central Nervous System Stimulants/toxicity; Methamphetamine/toxicity; Nerve Tissue Proteins/antagonists & inhibitors; Neuroprotective Agents/therapeutic use; Neurotoxicity Syndromes/prevention & control; Piperazines/therapeutic use; Receptors, sigma/antagonists & inhibitors; Animals; Benzoxazoles/adverse effects; Central Nervous System Stimulants/antagonists & inhibitors; Corpus Striatum/drug effects; Corpus Striatum/metabolism; Corpus Striatum/pathology; Dopamine/chemistry; Dopamine/metabolism; Dopamine Antagonists/adverse effects; Dopamine Antagonists/therapeutic use; Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors; Dopamine Plasma Membrane Transport Proteins/metabolism; Drug Synergism; Fever/etiology; Fever/prevention & control; Guanidines/adverse effects; Guanidines/therapeutic use; Male; Methamphetamine/antagonists & inhibitors; Mice; Nerve Tissue Proteins/agonists; Neurons/drug effects; Neurons/metabolism; Neurons/pathology; Neuroprotective Agents/adverse effects; Neurotoxicity Syndromes/metabolism; Neurotoxicity Syndromes/pathology; Neurotoxicity Syndromes/physiopathology; Piperazines/adverse effects; Random Allocation; Receptors, sigma/agonists; Serotonin/chemistry; Serotonin/metabolism; Serotonin Antagonists/adverse effects; Serotonin Antagonists/therapeutic use; Serotonin Plasma Membrane Transport Proteins/chemistry; Serotonin Plasma Membrane Transport Proteins/metabolism

Key words

Dopamine; Hyperthermia; Methamphetamine; Neurotoxicity; Serotonin; Sigma receptors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Benzoxazoles / Receptors, sigma / Neuroprotective Agents / Neurotoxicity Syndromes / Central Nervous System Stimulants / Methamphetamine / Nerve Tissue Proteins Type of study: Etiology_studies Language: En Journal: Eur Neuropsychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2013 Document type: Article Affiliation country: United States Country of publication: Netherlands

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