The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.

Seminerio, Michael J; Hansen, Rolf; Kaushal, Nidhi; Zhang, Han-Ting; McCurdy, Christopher R; Matsumoto, Rae R

Seminerio, Michael J; Hansen, Rolf; Kaushal, Nidhi; Zhang, Han-Ting; McCurdy, Christopher R; Matsumoto, Rae R.

Affiliation

Seminerio MJ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.

Int J Neuropsychopharmacol ; 16(5): 1033-44, 2013 Jun.

Article in En | MEDLINE | ID: mdl-22932447

Subject(s)

Benzothiazoles/therapeutic use; Dopamine Uptake Inhibitors/toxicity; Dopamine/metabolism; Memory Disorders/drug therapy; Methamphetamine/toxicity; Piperazines/therapeutic use; Analysis of Variance; Animals; Avoidance Learning/drug effects; Body Temperature/drug effects; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins/metabolism; Male; Memory Disorders/etiology; Mice; Neurotoxicity Syndromes/complications; Neurotoxicity Syndromes/etiology; Neurotransmitter Agents/pharmacokinetics; Protein Binding/drug effects; Receptors, sigma/antagonists & inhibitors; Recognition, Psychology/drug effects; Tritium/pharmacokinetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Dopamine / Dopamine Uptake Inhibitors / Benzothiazoles / Memory Disorders / Methamphetamine Type of study: Etiology_studies Limits: Animals Language: En Journal: Int J Neuropsychopharmacol Journal subject: NEUROLOGIA / PSICOFARMACOLOGIA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google