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Human ß-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.
Knight, Robin R; Kronenberg, Deborah; Zhao, Min; Huang, Guo Cai; Eichmann, Martin; Bulek, Anna; Wooldridge, Linda; Cole, David K; Sewell, Andrew K; Peakman, Mark; Skowera, Ania.
Affiliation
  • Knight RR; Department of Immunobiology, King's College London, London, United Kingdom.
Diabetes ; 62(1): 205-13, 2013 Jan.
Article in En | MEDLINE | ID: mdl-22936177
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Precursors / Receptors, Antigen, T-Cell / Cell Degranulation / CD8-Positive T-Lymphocytes / Cytotoxicity, Immunologic / Insulin-Secreting Cells / Insulin Limits: Humans Language: En Journal: Diabetes Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Precursors / Receptors, Antigen, T-Cell / Cell Degranulation / CD8-Positive T-Lymphocytes / Cytotoxicity, Immunologic / Insulin-Secreting Cells / Insulin Limits: Humans Language: En Journal: Diabetes Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United States