A drug-in-adhesive matrix based on thermoplastic elastomer: evaluation of percutaneous absorption, adhesion, and skin irritation.

Wang, ChengXiao; Liu, Ran; Tang, XiuZhen; Han, Wei

Wang, ChengXiao; Liu, Ran; Tang, XiuZhen; Han, Wei.

Affiliation

Wang C; School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.

AAPS PharmSciTech ; 13(4): 1179-89, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22961413

Subject(s)

Adhesives/chemistry; Capsaicin/chemistry; Elastomers/chemistry; Plasticizers/chemistry; Polymers/chemistry; Skin/drug effects; Adhesives/pharmacokinetics; Adhesives/pharmacology; Adhesives/toxicity; Animals; Butadienes/chemistry; Butadienes/pharmacokinetics; Butadienes/pharmacology; Butadienes/toxicity; Capsaicin/pharmacokinetics; Capsaicin/pharmacology; Capsaicin/toxicity; Chemistry, Pharmaceutical/methods; Diffusion; Elastomers/pharmacokinetics; Elastomers/pharmacology; Elastomers/toxicity; Hemiterpenes/chemistry; Hemiterpenes/pharmacokinetics; Hemiterpenes/pharmacology; Hemiterpenes/toxicity; Irritants/chemistry; Irritants/pharmacokinetics; Irritants/pharmacology; Irritants/toxicity; Male; Pentanes/chemistry; Pentanes/pharmacokinetics; Pentanes/pharmacology; Pentanes/toxicity; Permeability; Plasticizers/pharmacokinetics; Plasticizers/pharmacology; Plasticizers/toxicity; Polymers/pharmacokinetics; Polymers/pharmacology; Polymers/toxicity; Rats; Rats, Wistar; Skin/metabolism; Skin Absorption; Styrene/chemistry; Styrene/pharmacokinetics; Styrene/pharmacology; Styrene/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasticizers / Polymers / Skin / Capsaicin / Adhesives / Elastomers Language: En Journal: AAPS PharmSciTech Journal subject: FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: China Country of publication: United States

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