A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin.

Teshigawara, Kiyoshi; Kuboyama, Tomoharu; Shigyo, Michiko; Nagata, Aiko; Sugimoto, Kenji; Matsuya, Yuji; Tohda, Chihiro

Teshigawara, Kiyoshi; Kuboyama, Tomoharu; Shigyo, Michiko; Nagata, Aiko; Sugimoto, Kenji; Matsuya, Yuji; Tohda, Chihiro.

Affiliation

Teshigawara K; Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

Br J Pharmacol ; 168(4): 903-19, 2013 Feb.

Article in En | MEDLINE | ID: mdl-22978525

Subject(s)

Astrocytes/metabolism; Axons/drug effects; Dehydroepiandrosterone/analogs & derivatives; Spinal Cord Injuries/drug therapy; Spinal Cord Regeneration/drug effects; Vimentin/metabolism; Animals; Cicatrix/pathology; Cicatrix/prevention & control; Dehydroepiandrosterone/administration & dosage; Dehydroepiandrosterone/chemistry; Dehydroepiandrosterone/therapeutic use; Disease Models, Animal; Male; Mice; Mice, Inbred Strains; Molecular Structure; Motor Activity/drug effects; Recovery of Function; Spinal Cord Injuries/metabolism; Spinal Cord Injuries/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Axons / Vimentin / Astrocytes / Dehydroepiandrosterone / Spinal Cord Regeneration Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Br J Pharmacol Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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