A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects.

Dockens, Randy; Wang, Jun-Sheng; Castaneda, Lorna; Sverdlov, Oleksandr; Huang, Shu-Pang; Slemmon, Randy; Gu, Huidong; Wong, Oi; Li, Hewei; Berman, Robert M; Smith, Christina; Albright, Charles F; Tong, Gary

Dockens, Randy; Wang, Jun-Sheng; Castaneda, Lorna; Sverdlov, Oleksandr; Huang, Shu-Pang; Slemmon, Randy; Gu, Huidong; Wong, Oi; Li, Hewei; Berman, Robert M; Smith, Christina; Albright, Charles F; Tong, Gary.

Affiliation

Dockens R; Discovery Medicine Clinical Pharmacology, Bristol-Myers Squibb, Hopewell, NJ, USA.

Clin Pharmacokinet ; 51(10): 681-93, 2012 Oct 01.

Article in En | MEDLINE | ID: mdl-23018531

Subject(s)

Aging/blood; Aging/cerebrospinal fluid; Oxadiazoles/administration & dosage; Oxadiazoles/pharmacokinetics; Sulfonamides/administration & dosage; Sulfonamides/pharmacokinetics; Adolescent; Adult; Aged; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Oxadiazoles/adverse effects; Oxadiazoles/pharmacology; Sex Factors; Sulfonamides/adverse effects; Sulfonamides/pharmacology; Time Factors; Tissue Distribution; Young Adult

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Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Sulfonamides / Aging Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacokinet Year: 2012 Document type: Article Affiliation country: United States

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