Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.

He, Hai-Bing; Gao, Li-Xin; Deng, Qi-Feng; Ma, Wei-Ping; Tang, Chun-Lan; Qiu, Wen-Wei; Tang, Jie; Li, Jing-Ya; Li, Jia; Yang, Fan

He, Hai-Bing; Gao, Li-Xin; Deng, Qi-Feng; Ma, Wei-Ping; Tang, Chun-Lan; Qiu, Wen-Wei; Tang, Jie; Li, Jing-Ya; Li, Jia; Yang, Fan.

Affiliation

He HB; Shanghai Engineering Research Center of Molecular Theraputics and New Drug Development, East China Normal University, Shanghai 200062, China.

Bioorg Med Chem Lett ; 22(23): 7237-42, 2012 Dec 01.

Article in En | MEDLINE | ID: mdl-23067554

Subject(s)

Enzyme Inhibitors/chemical synthesis; Lithocholic Acid/analogs & derivatives; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors; Binding Sites; Catalytic Domain; Diabetes Mellitus, Type 2/drug therapy; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/therapeutic use; Humans; Kinetics; Lithocholic Acid/chemical synthesis; Lithocholic Acid/chemistry; Lithocholic Acid/therapeutic use; Molecular Docking Simulation; Obesity/drug therapy; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Lithocholic Acid Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: China Country of publication: United kingdom

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