Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of &#945;-synuclein and toxicity to PC12 cells.

Ma, Kai-Li; Song, Lian-Kun; Long, Whitney Annie; Yuan, Yu-He; Zhang, Ying; Song, Xiu-Yun; Niu, Fei; Han, Ning; Chen, Nai-Hong

Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of α-synuclein and toxicity to PC12 cells.

Ma, Kai-Li; Song, Lian-Kun; Long, Whitney Annie; Yuan, Yu-He; Zhang, Ying; Song, Xiu-Yun; Niu, Fei; Han, Ning; Chen, Nai-Hong.

Affiliation

Ma KL; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.

Brain Res Bull ; 90: 127-31, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23128054

Subject(s)

Exons/genetics; Insecticides/pharmacology; Rotenone/pharmacology; Sequence Deletion/genetics; alpha-Synuclein/metabolism; Analysis of Variance; Animals; Apoptosis/drug effects; Apoptosis/genetics; Flow Cytometry; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Models, Molecular; PC12 Cells/drug effects; PC12 Cells/metabolism; Protein Isoforms/genetics; Protein Isoforms/metabolism; Rats; Transfection; alpha-Synuclein/deficiency; alpha-Synuclein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rotenone / Exons / Sequence Deletion / Alpha-Synuclein / Insecticides Limits: Animals Language: En Journal: Brain Res Bull Year: 2013 Document type: Article Country of publication: United States

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