Characterization of long-circulating cationic nanoparticle formulations consisting of a two-stage PEGylation step for the delivery of siRNA in a breast cancer tumor model.

Ho, Emmanuel A; Osooly, Maryam; Strutt, Dita; Masin, Dana; Yang, Youngjoo; Yan, Hong; Bally, Marcel

Ho, Emmanuel A; Osooly, Maryam; Strutt, Dita; Masin, Dana; Yang, Youngjoo; Yan, Hong; Bally, Marcel.

Affiliation

Ho EA; University of Manitoba, Winnipeg, Manitoba, R3E 0T5, Canada. emmanuel_ho@umanitoba.ca

J Pharm Sci ; 102(1): 227-36, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23132529

Subject(s)

Breast Neoplasms/therapy; Gene Transfer Techniques; Genetic Therapy/methods; Nanoparticles; Polyethylene Glycols/chemistry; RNA Interference; RNA, Small Interfering/metabolism; Animals; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cations; Cell Line, Tumor; Female; Genes, Reporter; Liposomes; Liver/metabolism; Luciferases/genetics; Luciferases/metabolism; Mice; Microscopy, Fluorescence; RNA Stability; RNA, Small Interfering/blood; RNA, Small Interfering/chemistry; RNA, Small Interfering/pharmacokinetics; Tissue Distribution; Transfection; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Breast Neoplasms / Genetic Therapy / Gene Transfer Techniques / RNA, Small Interfering / RNA Interference / Nanoparticles Limits: Animals Language: En Journal: J Pharm Sci Year: 2013 Document type: Article Affiliation country: Canada Country of publication: United States

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