Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.

Hutcheson, Jack; Vanarsa, Kamala; Bashmakov, Anna; Grewal, Simer; Sajitharan, Deena; Chang, Betty Y; Buggy, Joseph J; Zhou, Xin J; Du, Yong; Satterthwaite, Anne B; Mohan, Chandra

Hutcheson, Jack; Vanarsa, Kamala; Bashmakov, Anna; Grewal, Simer; Sajitharan, Deena; Chang, Betty Y; Buggy, Joseph J; Zhou, Xin J; Du, Yong; Satterthwaite, Anne B; Mohan, Chandra.

Arthritis Res Ther ; 14(6): R243, 2012 Nov 08.

Article in En | MEDLINE | ID: mdl-23136880

Subject(s)

Autoimmunity/drug effects; Lupus Nephritis/prevention & control; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyrazoles/pharmacology; Pyrimidines/pharmacology; Signal Transduction/drug effects; Adenine/analogs & derivatives; Agammaglobulinaemia Tyrosine Kinase; Animals; Autoantibodies/blood; Autoantibodies/immunology; Autoimmunity/immunology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Kidney/drug effects; Kidney/immunology; Kidney/pathology; Lupus Erythematosus, Systemic/genetics; Lupus Erythematosus, Systemic/immunology; Lupus Nephritis/genetics; Lupus Nephritis/immunology; Lymphocytes/drug effects; Lymphocytes/immunology; Male; Mice, Congenic; Mice, Inbred C57BL; Piperidines; Protein-Tyrosine Kinases/immunology; Protein-Tyrosine Kinases/metabolism; Signal Transduction/immunology; Splenomegaly/immunology; Splenomegaly/prevention & control; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Lupus Nephritis / Protein-Tyrosine Kinases / Signal Transduction / Autoimmunity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Arthritis Res Ther Journal subject: REUMATOLOGIA Year: 2012 Document type: Article Country of publication: United kingdom

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