Antimicrobial peptide elicitors: new hope for the post-antibiotic era.
Innate Immun
; 19(3): 227-41, 2013 Jun.
Article
in En
| MEDLINE
| ID: mdl-23160387
Antimicrobial peptides or host defense peptides are fundamental components of human innate immunity. Recent and growing evidence suggests they have a role in a broad range of diseases, including cancer, allergies and susceptibility to infection, including HIV/AIDS. Antimicrobial peptide elicitors (APEs) are physical, biological or chemical agents that boost human antimicrobial peptide expression. The current knowledge of APEs and their potential use in the treatment of human infectious diseases are reviewed, and a classification system for APEs is proposed. The efficient use of APEs in clinical practice could mark the beginning of the urgently needed post-antibiotic era, but further trials assessing their efficacy and safety are required.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Bacterial Infections
/
Antimicrobial Cationic Peptides
Limits:
Animals
/
Humans
Language:
En
Journal:
Innate Immun
Journal subject:
ALERGIA E IMUNOLOGIA
/
BACTERIOLOGIA
Year:
2013
Document type:
Article
Affiliation country:
Mexico
Country of publication:
United States