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Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis.
Yan, S; Li, Y Z; Zhu, J W; Liu, C L; Wang, P; Liu, Y L.
Affiliation
  • Yan S; Department of Urological Surgery, Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Genet Mol Res ; 11(4): 3998-4007, 2012 Nov 26.
Article in En | MEDLINE | ID: mdl-23212337
We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529 T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529 T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529 T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome, Human / Polymorphism, Single Nucleotide / Caspase 10 / Neoplasms Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: Genet Mol Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2012 Document type: Article Affiliation country: China Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome, Human / Polymorphism, Single Nucleotide / Caspase 10 / Neoplasms Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: Genet Mol Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2012 Document type: Article Affiliation country: China Country of publication: Brazil