Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of Î³-secretase.

Kretner, Benedikt; Fukumori, Akio; Kuhn, Peer-Hendrik; Pérez-Revuelta, Blanca Isabel; Lichtenthaler, Stefan F; Haass, Christian; Steiner, Harald

Kretner, Benedikt; Fukumori, Akio; Kuhn, Peer-Hendrik; Pérez-Revuelta, Blanca Isabel; Lichtenthaler, Stefan F; Haass, Christian; Steiner, Harald.

Affiliation

Kretner B; Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

J Neurochem ; 125(1): 144-56, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23237322

Subject(s)

Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Protein Precursor/metabolism; Presenilin-1/metabolism; Amino Acid Motifs; Amyloid beta-Peptides/biosynthesis; Amyloid beta-Protein Precursor/genetics; Catalytic Domain; Glycine/genetics; HEK293 Cells; Humans; Leucine/genetics; Mutation; Presenilin-1/genetics; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / Amyloid Precursor Protein Secretases / Presenilin-1 Limits: Humans Language: En Journal: J Neurochem Year: 2013 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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