Induction of death of leukemia cells by TW-74, a novel derivative of chloro-naphthoquinone.

Hallak, Maher; Thakur, Basant K; Winn, Thida; Shpilberg, Ofer; Bittner, Shmuel; Granot, Yosef; Levy, Itai; Nathan, Ilana

Hallak, Maher; Thakur, Basant K; Winn, Thida; Shpilberg, Ofer; Bittner, Shmuel; Granot, Yosef; Levy, Itai; Nathan, Ilana.

Affiliation

Hallak M; Department. of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva, 84101 Israel.

Anticancer Res ; 33(1): 183-90, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23267144

Subject(s)

Apoptosis/drug effects; Leukemia, Myeloid, Acute/drug therapy; Mitochondria, Liver/drug effects; Naphthoquinones/administration & dosage; Animals; Caspases/metabolism; Cytochromes c/metabolism; HL-60 Cells/drug effects; Humans; Mitochondria, Liver/metabolism; Mitogen-Activated Protein Kinases/metabolism; Naphthoquinones/chemical synthesis; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Structure-Activity Relationship; U937 Cells/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria, Liver / Leukemia, Myeloid, Acute / Naphthoquinones / Apoptosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Anticancer Res Year: 2013 Document type: Article Country of publication: Greece

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