Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases.

Oruganty, Krishnadev; Talathi, Nakul Suhas; Wood, Zachary A; Kannan, Natarajan

Oruganty, Krishnadev; Talathi, Nakul Suhas; Wood, Zachary A; Kannan, Natarajan.

Affiliation

Oruganty K; Department of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.

Proc Natl Acad Sci U S A ; 110(3): 924-9, 2013 Jan 15.

Article in En | MEDLINE | ID: mdl-23277537

Subject(s)

Evolution, Molecular; Protein Kinases/chemistry; Protein Kinases/genetics; Amino Acid Substitution; Aurora Kinases; Catalysis; Catalytic Domain; Conserved Sequence; Enzyme Activation; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Protein Conformation; Protein Kinases/metabolism; Protein Serine-Threonine Kinases/chemistry; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Evolution, Molecular Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Document type: Article Affiliation country: United States

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