Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine.

Prosser, Gareth A; de Carvalho, Luiz Pedro S

Prosser, Gareth A; de Carvalho, Luiz Pedro S.

Affiliation

Prosser GA; Mycobacterial Research Division, Medical Research Council National Institute for Medical Research, London, UK.

FEBS J ; 280(4): 1150-66, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23286234

Subject(s)

Antibiotics, Antitubercular/chemistry; Bacterial Proteins/antagonists & inhibitors; Cycloserine/chemistry; Mycobacterium tuberculosis/enzymology; Peptide Synthases/antagonists & inhibitors; Adenosine Diphosphate/chemistry; Adenosine Triphosphate/chemistry; Alanine/chemistry; Bacterial Proteins/chemistry; Binding, Competitive; Dipeptides/chemistry; Hydrogen-Ion Concentration; Kinetics; Peptide Synthases/chemistry; Protein Binding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Synthases / Bacterial Proteins / Cycloserine / Antibiotics, Antitubercular / Mycobacterium tuberculosis Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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