Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells.

Zou, Jie; Li, Peng; Lu, Fei; Liu, Na; Dai, Jianjian; Ye, Jingjing; Qu, Xun; Sun, Xiulian; Ma, Daoxin; Park, Jino; Ji, Chunyan

Zou, Jie; Li, Peng; Lu, Fei; Liu, Na; Dai, Jianjian; Ye, Jingjing; Qu, Xun; Sun, Xiulian; Ma, Daoxin; Park, Jino; Ji, Chunyan.

Affiliation

Zou J; Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, 107 West Wenhua Road, Jinan, Shandong, 250012, People's Republic of China.

J Hematol Oncol ; 6: 3, 2013 Jan 05.

Article in En | MEDLINE | ID: mdl-23289374

Subject(s)

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology; Receptor, Notch1/metabolism; Cell Growth Processes/physiology; Cell Hypoxia/physiology; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Jurkat Cells; Matrix Metalloproteinase 2/biosynthesis; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/biosynthesis; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Neoplasm Invasiveness; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/genetics; Receptor, Notch1/genetics; Signal Transduction; Transfection; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Notch1 / Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2013 Document type: Article Country of publication: United kingdom

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