Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration.

Sul, Jee-Won; Park, Min-Young; Shin, Juhee; Kim, Young-Ran; Yoo, Sung-Eun; Kong, Young-Yun; Kwon, Ki-Sun; Lee, Young Ho; Kim, Eunhee

Sul, Jee-Won; Park, Min-Young; Shin, Juhee; Kim, Young-Ran; Yoo, Sung-Eun; Kong, Young-Yun; Kwon, Ki-Sun; Lee, Young Ho; Kim, Eunhee.

Affiliation

Sul JW; College of Biological Sciences and Biotechnology, School of Medicine, Chungnam National University, Daejeon, South Korea.

Hum Mol Genet ; 22(8): 1558-73, 2013 Apr 15.

Article in En | MEDLINE | ID: mdl-23307929

Subject(s)

Carrier Proteins/genetics; Nerve Degeneration/metabolism; Parkinson Disease/genetics; Parkinsonian Disorders; Ubiquitin-Protein Ligases/genetics; Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Carrier Proteins/metabolism; Dopaminergic Neurons/pathology; Humans; Intracellular Signaling Peptides and Proteins; Mice; Motor Activity/genetics; Mutation; Nerve Degeneration/pathology; Parkinson Disease/metabolism; Parkinson Disease/pathology; Parkinsonian Disorders/genetics; Parkinsonian Disorders/metabolism; Proteolysis; Ubiquitin-Protein Ligases/metabolism; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Carrier Proteins / Parkinsonian Disorders / Ubiquitin-Protein Ligases / Nerve Degeneration Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2013 Document type: Article Affiliation country: South Korea Country of publication: United kingdom

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