The 5-HT1D/1B receptor agonist sumatriptan enhances fear of simulated speaking and reduces plasma levels of prolactin.

de Rezende, Marcos Gonçalves; Garcia-Leal, Cybele; Graeff, Frederico Guilherme; Del-Ben, Cristina Marta

de Rezende, Marcos Gonçalves; Garcia-Leal, Cybele; Graeff, Frederico Guilherme; Del-Ben, Cristina Marta.

Affiliation

de Rezende MG; 1Department of Neuroscience and Behaviour, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

J Psychopharmacol ; 27(12): 1124-33, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23325368

Subject(s)

Fear/drug effects; Prolactin/blood; Serotonin 5-HT1 Receptor Agonists/pharmacology; Sumatriptan/pharmacology; Adult; Blood Pressure/physiology; Dose-Response Relationship, Drug; Double-Blind Method; Galvanic Skin Response/physiology; Heart Rate/physiology; Humans; Male; Nerve Net/physiology; Receptor, Serotonin, 5-HT1B/drug effects; Receptor, Serotonin, 5-HT1B/metabolism; Receptor, Serotonin, 5-HT1D/drug effects; Receptor, Serotonin, 5-HT1D/metabolism; Serotonin 5-HT1 Receptor Agonists/administration & dosage; Speech/physiology; Sumatriptan/administration & dosage; Young Adult

Key words

5-HT1D/1B receptor; Serotonin; anxiety; hypothalamicpituitaryadrenal axis; public speaking; sumatriptan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prolactin / Sumatriptan / Fear / Serotonin 5-HT1 Receptor Agonists Type of study: Clinical_trials Limits: Adult / Humans / Male Language: En Journal: J Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2013 Document type: Article Affiliation country: Brazil Country of publication: United States

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