Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells.

Sun, Xin; Gao, Rui-Lan; Lin, Xiao-Jie; Xu, Wei-Hong; Chen, Xiao-Hong

Sun, Xin; Gao, Rui-Lan; Lin, Xiao-Jie; Xu, Wei-Hong; Chen, Xiao-Hong.

Affiliation

Sun X; Department of Oncology, Zhejiang Provincial People's Hospital, Hangzhou, China.

Chin J Integr Med ; 19(2): 112-8, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23371459

Subject(s)

GATA Transcription Factors/metabolism; Hematopoietic Stem Cells/enzymology; Panax notoginseng/chemistry; Protein Kinases/metabolism; Saponins/pharmacology; Up-Regulation/drug effects; Blotting, Western; Cell Line, Tumor; DNA/metabolism; Electrophoretic Mobility Shift Assay; Extracellular Signal-Regulated MAP Kinases/metabolism; Hematopoietic Stem Cells/drug effects; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase Kinases/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphorylation/drug effects; Protein Binding/drug effects; Proto-Oncogene Proteins c-akt/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Saponins / Hematopoietic Stem Cells / Up-Regulation / GATA Transcription Factors / Panax notoginseng Limits: Humans Language: En Journal: Chin J Integr Med Journal subject: TERAPIAS COMPLEMENTARES Year: 2013 Document type: Article Affiliation country: China Country of publication: China

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