Hydrodynamics-based delivery of an interleukin-1 receptor II fusion gene ameliorates rat autoimmune myocarditis by inhibiting IL-1 and Th17 cell polarization.

Chang, He; Wang, Yan; Wu, Weiyin; Li, Gang; Hanawa, Haruo; Zou, Jun

Chang, He; Wang, Yan; Wu, Weiyin; Li, Gang; Hanawa, Haruo; Zou, Jun.

Affiliation

Chang H; Division of Cardiology, The Affiliated Zhongshan Hospital of Xiamen University, Xiamen Heart Center, Xiamen, Fujian, PR China.

Int J Mol Med ; 31(4): 833-40, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23403812

Subject(s)

Autoimmune Diseases/therapy; Genetic Therapy/methods; Myocarditis/therapy; Receptors, Interleukin-1 Type II/genetics; Transfection/methods; Analysis of Variance; Animals; Autoimmune Diseases/genetics; Autoimmune Diseases/metabolism; Cytokines/analysis; Cytokines/genetics; Cytokines/metabolism; Electrocardiography; Gene Expression Regulation; Heart Ventricles/metabolism; Heart Ventricles/pathology; Interleukin-1/metabolism; Male; Myocarditis/genetics; Myocarditis/metabolism; RNA, Messenger/analysis; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Rats, Inbred Lew; Receptors, Interleukin-1 Type II/analysis; Receptors, Interleukin-1 Type II/metabolism; Th17 Cells/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Transfection / Genetic Therapy / Receptors, Interleukin-1 Type II / Myocarditis Limits: Animals Language: En Journal: Int J Mol Med Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2013 Document type: Article Country of publication: Greece

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