Extracellular Matrix/metabolism; Fibrinolysin/metabolism; Matrix Metalloproteinases/metabolism; Vascular Endothelial Growth Factor A/chemistry; Vascular Endothelial Growth Factor A/pharmacology; Animals; Base Sequence; Binding Sites; Capillary Permeability; Cell Line, Tumor; Cell Proliferation; Endothelium, Vascular/metabolism; Extracellular Matrix/genetics; Gene Expression; Half-Life; Human Umbilical Vein Endothelial Cells; Humans; Male; Matrix Metalloproteinases/genetics; Mice; Molecular Sequence Data; Pichia/genetics; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Isoforms/metabolism; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Recombinant Fusion Proteins/pharmacology; Umbilical Veins/metabolism; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism