Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1&#945; pathways under hypoxia.

Onishi, Hideya; Morisaki, Takafumi; Nakao, Fumihiko; Odate, Seiichi; Morisaki, Takashi; Katano, Mitsuo

Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia.

Onishi, Hideya; Morisaki, Takafumi; Nakao, Fumihiko; Odate, Seiichi; Morisaki, Takashi; Katano, Mitsuo.

Affiliation

Onishi H; Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ohnishi@surg1.med.kyushu-u.ac.jp

Cancer Lett ; 335(2): 289-98, 2013 Jul 28.

Article in En | MEDLINE | ID: mdl-23485726

Subject(s)

Carcinoma, Pancreatic Ductal/drug therapy; Hedgehog Proteins/metabolism; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Pancreatic Neoplasms/drug therapy; Proteoglycans/pharmacology; Animals; Antibiotics, Antineoplastic/pharmacology; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation/drug effects; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Matrix Metalloproteinase 2/biosynthesis; Matrix Metalloproteinase 9/biosynthesis; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Polysaccharides; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription Factors/genetics; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Proteoglycans / Carcinoma, Pancreatic Ductal / Hypoxia-Inducible Factor 1, alpha Subunit / Hedgehog Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Lett Year: 2013 Document type: Article Affiliation country: Japan Country of publication: Ireland

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