A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

Kwan, Elizabeth X; Foss, Eric J; Tsuchiyama, Scott; Alvino, Gina M; Kruglyak, Leonid; Kaeberlein, Matt; Raghuraman, M K; Brewer, Bonita J; Kennedy, Brian K; Bedalov, Antonio

Kwan, Elizabeth X; Foss, Eric J; Tsuchiyama, Scott; Alvino, Gina M; Kruglyak, Leonid; Kaeberlein, Matt; Raghuraman, M K; Brewer, Bonita J; Kennedy, Brian K; Bedalov, Antonio.

Affiliation

Kwan EX; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

PLoS Genet ; 9(3): e1003329, 2013.

Article in En | MEDLINE | ID: mdl-23505383

Subject(s)

Aging/genetics; DNA, Ribosomal/genetics; Quantitative Trait Loci/genetics; Saccharomyces cerevisiae; Caloric Restriction; DNA Replication/genetics; DNA, Ribosomal/physiology; DNA-Binding Proteins/genetics; Gene Expression Regulation, Fungal/genetics; Longevity/genetics; Polymorphism, Genetic; Replication Origin/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae Proteins/genetics; Sirtuin 2/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Aging / DNA, Ribosomal / Quantitative Trait Loci Type of study: Prognostic_studies Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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