Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice.

Fujii, Masanori; Nakashima, Hiroyuki; Tomozawa, Junko; Shimazaki, Yuki; Ohyanagi, Chie; Kawaguchi, Naomi; Ohya, Susumu; Kohno, Shigekatsu; Nabe, Takeshi

Fujii, Masanori; Nakashima, Hiroyuki; Tomozawa, Junko; Shimazaki, Yuki; Ohyanagi, Chie; Kawaguchi, Naomi; Ohya, Susumu; Kohno, Shigekatsu; Nabe, Takeshi.

Affiliation

Fujii M; Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan. fujii@mb.kyoto-phu.ac.jp

Exp Dermatol ; 22(4): 272-7, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23528213

Subject(s)

Dermatitis, Atopic/etiology; Fatty Acids, Omega-6/deficiency; Animals; Arachidonic Acid/administration & dosage; Dermatitis, Atopic/diet therapy; Dermatitis, Atopic/metabolism; Diet/adverse effects; Dietary Fats, Unsaturated/administration & dosage; Disease Models, Animal; Fatty Acids/blood; Fatty Acids/metabolism; Fatty Acids, Omega-3/metabolism; Fatty Acids, Omega-6/blood; Fatty Acids, Omega-6/metabolism; Female; Linoleic Acid/administration & dosage; Linoleic Acid/metabolism; Mice; Mice, Hairless; Pruritus/etiology; Pruritus/metabolism; Pruritus/pathology; Skin/metabolism; Skin/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fatty Acids, Omega-6 / Dermatitis, Atopic Type of study: Etiology_studies Limits: Animals Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2013 Document type: Article Affiliation country: Japan Country of publication: Denmark

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