Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.

Zhang, Yi; Albohy, Amgad; Zou, Yao; Smutova, Victoria; Pshezhetsky, Alexey V; Cairo, Christopher W

Zhang, Yi; Albohy, Amgad; Zou, Yao; Smutova, Victoria; Pshezhetsky, Alexey V; Cairo, Christopher W.

Affiliation

Zhang Y; Alberta Glycomics Center, Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

J Med Chem ; 56(7): 2948-58, 2013 Apr 11.

Article in En | MEDLINE | ID: mdl-23530623

Subject(s)

Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Isoenzymes/antagonists & inhibitors; N-Acetylneuraminic Acid/analogs & derivatives; Neuraminidase/antagonists & inhibitors; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; N-Acetylneuraminic Acid/pharmacology; Spectrometry, Mass, Electrospray Ionization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: N-Acetylneuraminic Acid / Enzyme Inhibitors / Isoenzymes / Neuraminidase Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Canada

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