Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increases peptide-membrane interactions potentiating its action.

Hollmann, Axel; Matos, Pedro M; Augusto, Marcelo T; Castanho, Miguel A R B; Santos, Nuno C

Hollmann, Axel; Matos, Pedro M; Augusto, Marcelo T; Castanho, Miguel A R B; Santos, Nuno C.

Affiliation

Hollmann A; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

PLoS One ; 8(4): e60302, 2013.

Article in En | MEDLINE | ID: mdl-23565220

Subject(s)

Cell Membrane/drug effects; Cell Membrane/metabolism; Cholesterol/chemistry; HIV Envelope Protein gp41/chemistry; HIV Envelope Protein gp41/pharmacology; Membrane Potentials/drug effects; Peptide Fragments/chemistry; Peptide Fragments/pharmacology; Amino Acid Sequence; Biological Transport; Erythrocytes/metabolism; HIV Fusion Inhibitors/chemistry; HIV Fusion Inhibitors/pharmacology; Humans; Leukocytes, Mononuclear/metabolism; Lipid Bilayers/metabolism; Lipids/chemistry; Membrane Fusion; Membrane Microdomains; Molecular Sequence Data; Sequence Alignment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / HIV Envelope Protein gp41 / Cell Membrane / Cholesterol / Membrane Potentials Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: Portugal Country of publication: United States

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