Evidence that low protein C contributes to the procoagulant imbalance in cirrhosis.

Tripodi, Armando; Primignani, Massimo; Lemma, Laura; Chantarangkul, Veena; Mannucci, Pier Mannuccio

Tripodi, Armando; Primignani, Massimo; Lemma, Laura; Chantarangkul, Veena; Mannucci, Pier Mannuccio.

Affiliation

Tripodi A; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy. armando.tripodi@unimi.it

J Hepatol ; 59(2): 265-70, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23583273

Subject(s)

Blood Coagulation; Liver Cirrhosis/blood; Protein C/metabolism; Aged; Aged, 80 and over; Blood Coagulation/drug effects; Blood Coagulation/physiology; Blood Coagulation Factors/metabolism; Blood Coagulation Tests; Female; Humans; Intercellular Signaling Peptides and Proteins; Liver Cirrhosis/complications; Male; Middle Aged; Peptides/pharmacology; Protein C/therapeutic use; Protein C Deficiency/blood; Protein C Deficiency/complications; Protein C Deficiency/drug therapy; Risk Factors; Thrombin/biosynthesis; Thrombomodulin/blood; Venous Thromboembolism/blood; Venous Thromboembolism/etiology; Venous Thromboembolism/prevention & control

Key words

ETP; Factor VIII; PICI; Protac®; Protac®-induced-coagulation inhibition; Thrombin generation; Thrombomodulin; endogenous thrombin potential

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Coagulation / Protein C / Liver Cirrhosis Type of study: Etiology_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2013 Document type: Article Affiliation country: Italy Country of publication: Netherlands

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