FBXL2- and PTPL1-mediated degradation of p110-free p85ß regulatory subunit controls the PI(3)K signalling cascade.

Kuchay, Shafi; Duan, Shanshan; Schenkein, Emily; Peschiaroli, Angelo; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Pagano, Michele

FBXL2- and PTPL1-mediated degradation of p110-free p85ß regulatory subunit controls the PI(3)K signalling cascade.

Kuchay, Shafi; Duan, Shanshan; Schenkein, Emily; Peschiaroli, Angelo; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Pagano, Michele.

Affiliation

Kuchay S; Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA.

Nat Cell Biol ; 15(5): 472-80, 2013 May.

Article in En | MEDLINE | ID: mdl-23604317

Subject(s)

Class Ia Phosphatidylinositol 3-Kinase/metabolism; F-Box Proteins/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 13/metabolism; Signal Transduction; Autophagy; Class Ia Phosphatidylinositol 3-Kinase/genetics; Enzyme Activation; Enzyme Stability; F-Box Proteins/genetics; Gene Silencing; HEK293 Cells; HeLa Cells; Humans; Immunoblotting; Insulin Receptor Substrate Proteins/metabolism; Phosphorylation; Proteasome Endopeptidase Complex/metabolism; Protein Binding; Protein Interaction Mapping; Protein Tyrosine Phosphatase, Non-Receptor Type 13/genetics; Proteolysis; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Transfection; Tyrosine/metabolism; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / F-Box Proteins / Protein Tyrosine Phosphatase, Non-Receptor Type 13 / Class Ia Phosphatidylinositol 3-Kinase Limits: Humans Language: En Journal: Nat Cell Biol Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

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