Telomere-homologous G-rich oligonucleotides sensitize human ovarian cancer cells to TRAIL-induced growth inhibition and apoptosis.

Sarkar, Sibaji; Faller, Douglas V

Sarkar, Sibaji; Faller, Douglas V.

Affiliation

Sarkar S; Cancer Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

Nucleic Acid Ther ; 23(3): 167-74, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23634944

Subject(s)

Antineoplastic Agents/pharmacology; Gene Expression Regulation, Neoplastic/drug effects; Oligonucleotides/pharmacology; Signal Transduction/drug effects; TNF-Related Apoptosis-Inducing Ligand/pharmacology; Telomere/drug effects; Apoptosis/drug effects; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism; Caspase 3/genetics; Caspase 3/metabolism; Caspase 7/genetics; Caspase 7/metabolism; Caspase 8/genetics; Caspase 8/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Drug Synergism; Female; Gene Expression Profiling; Humans; MAP Kinase Kinase 4/genetics; MAP Kinase Kinase 4/metabolism; Oligonucleotides/genetics; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/genetics; Ovarian Neoplasms/metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism; Recombinant Proteins/pharmacology; Telomere/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Signal Transduction / Gene Expression Regulation, Neoplastic / Telomere / TNF-Related Apoptosis-Inducing Ligand / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Nucleic Acid Ther Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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