Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aß deposition and tau pathology in 3xTg-AD mice.

Rasool, Suhail; Martinez-Coria, Hilda; Wu, Jessica W; LaFerla, Frank; Glabe, Charles G

Rasool, Suhail; Martinez-Coria, Hilda; Wu, Jessica W; LaFerla, Frank; Glabe, Charles G.

Affiliation

Rasool S; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA. suhailrasool@hotmail.com

J Neurochem ; 126(4): 473-82, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23672786

Subject(s)

Alzheimer Disease/therapy; Amyloid beta-Peptides/immunology; Antibodies, Monoclonal/pharmacology; Peptide Fragments/immunology; Tauopathies/therapy; Vaccination/methods; Alzheimer Disease/immunology; Alzheimer Disease/pathology; Amyloid beta-Peptides/genetics; Amyloid beta-Peptides/metabolism; Animals; Avoidance Learning; Cognition; Cognition Disorders/immunology; Cognition Disorders/pathology; Cognition Disorders/therapy; Disease Models, Animal; Female; Gene Knock-In Techniques; Maze Learning; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Microglia/immunology; Microglia/pathology; Peptide Fragments/genetics; Peptide Fragments/metabolism; Presenilin-1/genetics; Tauopathies/immunology; Tauopathies/pathology; tau Proteins/genetics

Key words

Alzheimer's disease; abeta oligomers; amyloid plaques; monoclonal antibodies; tau pathology; vaccination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Amyloid beta-Peptides / Vaccination / Tauopathies / Alzheimer Disease / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

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