BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.

Lu, Bai; Nagappan, Guhan; Guan, Xiaoming; Nathan, Pradeep J; Wren, Paul

Lu, Bai; Nagappan, Guhan; Guan, Xiaoming; Nathan, Pradeep J; Wren, Paul.

Affiliation

Lu B; GlaxoSmithKline, R&D China, Shanghai, 201203, China. bai.b.lu@gsk.com

Nat Rev Neurosci ; 14(6): 401-16, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23674053

Subject(s)

Brain-Derived Neurotrophic Factor/physiology; Brain-Derived Neurotrophic Factor/therapeutic use; Molecular Targeted Therapy/methods; Neurodegenerative Diseases/drug therapy; Neurogenesis/physiology; Neuronal Plasticity/physiology; Synapses/physiology; Animals; Brain-Derived Neurotrophic Factor/genetics; Humans; Neurogenesis/genetics; Neuronal Plasticity/genetics; Polymorphism, Single Nucleotide/physiology; Receptor, trkB/agonists; Receptor, trkB/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Brain-Derived Neurotrophic Factor / Neurodegenerative Diseases / Neurogenesis / Molecular Targeted Therapy / Neuronal Plasticity Limits: Animals / Humans Language: En Journal: Nat Rev Neurosci Journal subject: NEUROLOGIA Year: 2013 Document type: Article Affiliation country: China Country of publication: United kingdom

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