Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic &#945;2A-adrenergic receptor.

Wang, Yiyang; Yu, Xiaohui; Wang, Faqiang; Wang, Yuan; Wang, Yanping; Li, Hongmei; Lv, Xiuxiu; Lu, Daxiang; Wang, Huadong

Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor.

Wang, Yiyang; Yu, Xiaohui; Wang, Faqiang; Wang, Yuan; Wang, Yanping; Li, Hongmei; Lv, Xiuxiu; Lu, Daxiang; Wang, Huadong.

Affiliation

Wang Y; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.

PLoS One ; 8(5): e63622, 2013.

Article in En | MEDLINE | ID: mdl-23691077

Subject(s)

Heart/drug effects; Heart/metabolism; Lipopolysaccharides/pharmacology; Norepinephrine/metabolism; Receptors, Adrenergic, alpha-2/metabolism; Synapses/metabolism; Yohimbine/pharmacology; Adrenergic alpha-2 Receptor Antagonists/pharmacology; Animals; Apoptosis/drug effects; Heart/physiopathology; Liver/drug effects; Liver/physiopathology; Male; Mice; Mice, Inbred BALB C; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Nitric Oxide/biosynthesis; Organ Specificity; Presynaptic Terminals/drug effects; Protein Transport/drug effects; Reserpine/pharmacology; Synapses/drug effects; Tumor Necrosis Factor-alpha/biosynthesis

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Yohimbine / Norepinephrine / Lipopolysaccharides / Receptors, Adrenergic, alpha-2 / Heart Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: China Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google