Angiogenesis Inhibitors/toxicity; Carcinoma, Hepatocellular/secondary; Indoles/toxicity; Interleukin-12 Subunit p40/physiology; Liver Neoplasms/pathology; Lung Neoplasms/secondary; Niacinamide/analogs & derivatives; Phenylurea Compounds/toxicity; Pyrroles/toxicity; Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors; Angiogenesis Inhibitors/administration & dosage; Angiogenesis Inhibitors/pharmacology; Animals; Carcinoma, Hepatocellular/blood supply; Cell Line, Tumor; Dendritic Cells/immunology; Diphosphonates/therapeutic use; Heterografts; Humans; Imidazoles/therapeutic use; Immunosuppression Therapy; Indoles/administration & dosage; Indoles/pharmacology; Interleukin-12 Subunit p40/deficiency; Interleukin-12 Subunit p40/genetics; Killer Cells, Natural/immunology; Lung Neoplasms/blood supply; Macrophages/immunology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neoplasm Transplantation; Neoplastic Cells, Circulating; Neovascularization, Pathologic/drug therapy; Niacinamide/administration & dosage; Niacinamide/pharmacology; Niacinamide/toxicity; Phenylurea Compounds/administration & dosage; Phenylurea Compounds/pharmacology; Pyrroles/administration & dosage; Pyrroles/pharmacology; Sorafenib; Sunitinib; Zoledronic Acid