Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

Jiang, Dawei; Zhao, Linlin; Clish, Clary B; Clapham, David E

Jiang, Dawei; Zhao, Linlin; Clish, Clary B; Clapham, David E.

Affiliation

Jiang D; Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, Boston, MA 02115, USA.

Proc Natl Acad Sci U S A ; 110(24): E2249-54, 2013 Jun 11.

Article in En | MEDLINE | ID: mdl-23716663

Subject(s)

Brain/metabolism; Calcium-Binding Proteins/metabolism; Glucose/metabolism; Membrane Proteins/metabolism; Wolf-Hirschhorn Syndrome/metabolism; Adenosine Triphosphate/metabolism; Animals; Antiporters/genetics; Antiporters/metabolism; Calcium/metabolism; Calcium-Binding Proteins/genetics; Cells, Cultured; Embryo, Mammalian/cytology; Embryo, Mammalian/embryology; Embryo, Mammalian/metabolism; Female; HEK293 Cells; Humans; Kainic Acid/toxicity; Male; Membrane Potential, Mitochondrial; Membrane Proteins/genetics; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Electron; Mitochondria/metabolism; Mitochondria/physiology; Mitochondria/ultrastructure; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Protons; RNA Interference; Seizures/chemically induced; Seizures/genetics; Seizures/physiopathology; Wolf-Hirschhorn Syndrome/genetics

Key words

calcium signaling; epilepsy; mitochondria

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Calcium-Binding Proteins / Wolf-Hirschhorn Syndrome / Glucose / Membrane Proteins Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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