Engineering human T cells for resistance to methotrexate and mycophenolate mofetil as an in vivo cell selection strategy.

Jonnalagadda, Mahesh; Brown, Christine E; Chang, Wen-Chung; Ostberg, Julie R; Forman, Stephen J; Jensen, Michael C

Jonnalagadda, Mahesh; Brown, Christine E; Chang, Wen-Chung; Ostberg, Julie R; Forman, Stephen J; Jensen, Michael C.

Affiliation

Jonnalagadda M; Departments of Cancer Immunotherapeutics & Tumor Immunology, and Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope, Duarte, California, United States of America.

PLoS One ; 8(6): e65519, 2013.

Article in En | MEDLINE | ID: mdl-23755242

Subject(s)

Methotrexate/pharmacology; Mycophenolic Acid/analogs & derivatives; T-Lymphocytes/drug effects; T-Lymphocytes/metabolism; Animals; Cells, Cultured; Cytokines/metabolism; Flow Cytometry; Humans; IMP Dehydrogenase/genetics; IMP Dehydrogenase/metabolism; Interleukin-15/metabolism; Lentivirus/genetics; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/metabolism; Mice; Mycophenolic Acid/pharmacology; Tetrahydrofolate Dehydrogenase/genetics; Tetrahydrofolate Dehydrogenase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Methotrexate / Mycophenolic Acid Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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