α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata.
Fitoterapia
; 90: 30-7, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23856092
ABSTRACT
A phytochemical study on the ethanolic extract of the stem barks of Uncaria laevigata leads to the isolation and characterization of 18 triterpenoid compounds. Ten of these are new, including one novel heptanortriterpenoid (1), four ursane triterpenes (2-4, 10), and five oleanane triterpenes (5-9). Their structures were established by spectroscopic methods, especially by 2D-NMR and MS analyses. All these isolates were evaluated for their inhibitory effects on α-glucosidase ursolic acid and 3 showed potent activities with IC50 values of 16 ± 2.2 and 49 ± 3.7 µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triterpenes
/
Plant Extracts
/
Uncaria
/
Enzyme Inhibitors
/
Glycoside Hydrolase Inhibitors
Language:
En
Journal:
Fitoterapia
Year:
2013
Document type:
Article