pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis.

Sheen, Patricia; Lozano, Katherine; Gilman, Robert H; Valencia, Hugo J; Loli, Sebastian; Fuentes, Patricia; Grandjean, Louis; Zimic, Mirko

Sheen, Patricia; Lozano, Katherine; Gilman, Robert H; Valencia, Hugo J; Loli, Sebastian; Fuentes, Patricia; Grandjean, Louis; Zimic, Mirko.

Affiliation

Sheen P; Unidad de Bioinformática y Biología Molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, SMP, Lima, Peru.

Tuberculosis (Edinb) ; 93(5): 515-22, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23867321

Subject(s)

Amidohydrolases/genetics; Antitubercular Agents/pharmacology; Mycobacterium tuberculosis/metabolism; Pyrazinamide/pharmacology; Amidohydrolases/biosynthesis; Amidohydrolases/metabolism; Drug Resistance, Bacterial/genetics; Drug Resistance, Bacterial/physiology; Genes, Bacterial; Humans; Microbial Sensitivity Tests/methods; Mutation; Mycobacterium tuberculosis/drug effects; Mycobacterium tuberculosis/genetics; Promoter Regions, Genetic/genetics; Pyrazinamide/analogs & derivatives; Pyrazinamide/metabolism; RNA, Bacterial/genetics; RNA, Messenger/genetics

Key words

Mycobacterium tuberculosis; POA efflux rate; PZA resistance; PZAse activity; pncA expression level

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazinamide / Amidohydrolases / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Tuberculosis (Edinb) Year: 2013 Document type: Article Affiliation country: Peru Country of publication: United kingdom

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