Suggested phylogeny of tRNAs based on the construction of ancestral sequences.
J Theor Biol
; 335: 245-8, 2013 Oct 21.
Article
in En
| MEDLINE
| ID: mdl-23871958
The origin and evolution of life on the planet is one of the most intriguing challenges in life sciences and, for some researchers, it is centered in the origin of the genetic code. Many hypotheses about the origin and evolution of tRNA have been proposed and in this work a new suggestion is proposed based on the reconstruction of tRNA ancestor sequences. Ancestral sequences of 22 types of tRNA molecules were built by maximum likelihood from 9758 sequences currently reported from different organisms. Phylogenetic analysis showed that the main force for evolutionary diversification of tRNA molecules was a change in the second base of the anticodon. The data revealed that diversification is not correlated with the characteristic of the specified amino acid, indicating that the correlation between tRNA and amino acid was given indirectly, and possibly should have been mediated by proto-aminoacyl-tRNA synthetases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phylogeny
/
Anticodon
/
Evolution, Molecular
/
Models, Genetic
Type of study:
Prognostic_studies
Language:
En
Journal:
J Theor Biol
Year:
2013
Document type:
Article
Affiliation country:
Brazil
Country of publication:
United kingdom