Nifedipine inhibits angiotensin II-induced cardiac fibrosis via downregulating Nox4-derived ROS generation and suppressing ERK1/2, JNK signaling pathways.

Jia, Yanyan; Xu, Jian; Yu, Yang; Guo, Jinlei; Liu, Peiqing; Chen, Shaorui; Jiang, Jianmin

Jia, Yanyan; Xu, Jian; Yu, Yang; Guo, Jinlei; Liu, Peiqing; Chen, Shaorui; Jiang, Jianmin.

Affiliation

Jia Y; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

Pharmazie ; 68(6): 435-41, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23875251

Subject(s)

Angiotensin II/pharmacology; Calcium Channel Blockers/pharmacology; Heart Diseases/chemically induced; Heart Diseases/prevention & control; MAP Kinase Signaling System/drug effects; NADPH Oxidases/biosynthesis; Nifedipine/pharmacology; Reactive Oxygen Species/metabolism; Vasoconstrictor Agents/antagonists & inhibitors; Actins/biosynthesis; Animals; Blotting, Western; Calcium Signaling/drug effects; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Cell Separation; Connective Tissue Growth Factor/biosynthesis; Down-Regulation/drug effects; Fibronectins/biosynthesis; Fibrosis; Fluorescent Antibody Technique; Heart Diseases/pathology; In Vitro Techniques; Male; NADPH Oxidase 4; NADPH Oxidases/antagonists & inhibitors; NADPH Oxidases/genetics; Phosphorylation; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Vasoconstrictor Agents / Angiotensin II / Calcium Channel Blockers / Nifedipine / Reactive Oxygen Species / NADPH Oxidases / MAP Kinase Signaling System / Heart Diseases Limits: Animals Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2013 Document type: Article Affiliation country: China Country of publication: Germany

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