Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling.

Fan, Martin; Sidhu, Rohini; Fujiwara, Hideji; Tortelli, Brett; Zhang, Jessie; Davidson, Cristin; Walkley, Steven U; Bagel, Jessica H; Vite, Charles; Yanjanin, Nicole M; Porter, Forbes D; Schaffer, Jean E; Ory, Daniel S

Fan, Martin; Sidhu, Rohini; Fujiwara, Hideji; Tortelli, Brett; Zhang, Jessie; Davidson, Cristin; Walkley, Steven U; Bagel, Jessica H; Vite, Charles; Yanjanin, Nicole M; Porter, Forbes D; Schaffer, Jean E; Ory, Daniel S.

Affiliation

Fan M; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, St. Louis, MO.

J Lipid Res ; 54(10): 2800-14, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23881911

Subject(s)

Niemann-Pick Disease, Type C/blood; Sphingolipids/blood; 1-Deoxynojirimycin/analogs & derivatives; 1-Deoxynojirimycin/pharmacology; 1-Deoxynojirimycin/therapeutic use; 2-Hydroxypropyl-beta-cyclodextrin; Animals; Biomarkers/blood; Biomarkers/cerebrospinal fluid; Cats; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Female; Gangliosides/blood; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Niemann-Pick Disease, Type C/diagnosis; Niemann-Pick Disease, Type C/drug therapy; Organ Specificity; Sphingolipids/cerebrospinal fluid; Sulfoglycosphingolipids/blood; Tandem Mass Spectrometry; beta-Cyclodextrins/pharmacology; beta-Cyclodextrins/therapeutic use

Key words

metabolomics; neurodegeneration; sphingolipids

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingolipids / Niemann-Pick Disease, Type C Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Lipid Res Year: 2013 Document type: Article Affiliation country: Macao Country of publication: United States

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