Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells.

Kaulfuß, Silke; Seemann, Henning; Kampe, Rovena; Meyer, Julia; Dressel, Ralf; König, Britta; Scharf, Jens-Gerd; Burfeind, Peter

Kaulfuß, Silke; Seemann, Henning; Kampe, Rovena; Meyer, Julia; Dressel, Ralf; König, Britta; Scharf, Jens-Gerd; Burfeind, Peter.

Affiliation

Kaulfuß S; Institute of Human Genetics, University Medical Center Göttingen, Germany. silke@kaulfuss.eu

Oncotarget ; 4(7): 1037-49, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23900414

Subject(s)

Colorectal Neoplasms/enzymology; Colorectal Neoplasms/therapy; Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors; src-Family Kinases/antagonists & inhibitors; Apoptosis/drug effects; Apoptosis/genetics; Caco-2 Cells; Cell Cycle/drug effects; Cell Cycle/genetics; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms/genetics; Colorectal Neoplasms/pathology; HCT116 Cells; HT29 Cells; Humans; Protein Kinase Inhibitors/pharmacology; Quinolines/pharmacology; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/genetics; Receptor, Platelet-Derived Growth Factor beta/antagonists & inhibitors; Receptor, Platelet-Derived Growth Factor beta/genetics; Receptors, Platelet-Derived Growth Factor/metabolism; Signal Transduction; src-Family Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Receptors, Platelet-Derived Growth Factor / Src-Family Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2013 Document type: Article Affiliation country: Germany Country of publication: United States

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